Bladder Cancer Research
The evaluation and treatment of bladder cancer is a complex process that typically involves multiple procedures and care providers. Dr. Paul Crispen’s research aims to improve the care of all stages of bladder cancer through clinical and basic science research.
Dissecting the Mechanisms of Tumor-Induced Tolerance and Immune Suppression in Bladder Cancer
Several cancer types, including bladder cancer, are highly enriched with hyaluronan (HA). HA-mediated signaling accomplished by its interaction with the cell surface receptor CD44. In this project, we propose to investigate the roles of HA-mediated CD44 signaling in mechanisms of tumor-induced immune suppression. We recently reported that co-culture of bone marrow-derived myeloid cells with tumor cells promotes differentiation of myeloid precursors toward highly immunosuppressive PD-L1+F4/80+macrophages (Prima et al., PNAS, 2017).
The investigators plan to start enrollment by fall 2018.
The Association with Bladder Cancer and Infection
Current basic science research at the University of Florida is evaluating the potential role of urinary tract infections and the development of bladder cancer and the evaluation of cellular sugar molecules in bladder cancer progression.
Strategies to Improve Bladder Cancer Surgery Outcomes
Clinical research projects include improving detection of recurrent bladder cancer during surveillance following initial treatment and multiple studies aimed at improving outcomes of patients undergoing bladder removal surgery.
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